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Seppo Ylä-Herttuala Selected Research

Infarction (Infarctions)

1/2022Adenoviral VEGF-DΔN ΔC gene therapy for myocardial ischemia.
10/2021Citrate-Saline-Formulated mRNA Delivery into the Heart Muscle with an Electromechanical Mapping and Injection Catheter Does Not Lead to Therapeutic Effects in a Porcine Chronic Myocardial Ischemia Model.
12/2017Aggravated Postinfarct Heart Failure in Type 2 Diabetes Is Associated with Impaired Mitophagy and Exaggerated Inflammasome Activation.
6/2017Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction.
1/2017Enhancing Angiogenesis in Mice by VEGF-Targeting Small Activating RNAs.
1/2014Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice.
11/2013The bottleneck stent model for chronic myocardial ischemia and heart failure in pigs.

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Seppo Ylä-Herttuala Research Topics

Disease

56Atherosclerosis
04/2024 - 01/2002
52Neoplasms (Cancer)
03/2024 - 02/2002
38Inflammation (Inflammations)
01/2022 - 05/2002
24Atherosclerotic Plaque (Atheroma)
01/2023 - 11/2002
24Glioma (Gliomas)
01/2020 - 03/2002
20Cardiovascular Diseases (Cardiovascular Disease)
11/2023 - 11/2003
17Hypoxia (Hypoxemia)
11/2023 - 04/2002
17Ischemia
08/2023 - 04/2002
14Myocardial Infarction
04/2024 - 11/2005
11Myocardial Ischemia (Ischemic Heart Diseases)
01/2022 - 06/2003
9Heart Failure
01/2024 - 01/2011
9Infections
11/2023 - 03/2003
9Ovarian Neoplasms (Ovarian Cancer)
01/2022 - 12/2010
9Type 2 Diabetes Mellitus (MODY)
01/2021 - 01/2003
9Lymphedema (Milroy Disease)
07/2015 - 07/2002
8Coronary Artery Disease (Coronary Atherosclerosis)
01/2024 - 06/2011
7Neoplasm Metastasis (Metastasis)
03/2024 - 12/2007
7Coronary Disease (Coronary Heart Disease)
12/2022 - 06/2003
7Infarction (Infarctions)
01/2022 - 11/2013
7Fibrosis (Cirrhosis)
01/2021 - 02/2012
7Wounds and Injuries (Trauma)
01/2019 - 11/2004
5Cardiomegaly (Heart Hypertrophy)
04/2024 - 10/2008
5Edema (Dropsy)
01/2023 - 09/2002
5Ovarian Epithelial Carcinoma
01/2020 - 03/2004
5Neointima
01/2016 - 03/2004
5Insulin Resistance
01/2016 - 01/2003
5Carcinoma (Carcinomatosis)
09/2014 - 06/2008
4Hypercholesterolemia
01/2021 - 01/2019
4Hemangioma (Angioma)
01/2019 - 01/2013
4Thrombosis (Thrombus)
01/2018 - 01/2005
4Vascular Diseases (Vascular Disease)
03/2014 - 04/2007
4Hypertrophy
12/2012 - 10/2008
3Choroidal Neovascularization
11/2022 - 02/2012
3Hyperlipidemias (Hyperlipidemia)
01/2022 - 07/2015
3Ascites
01/2022 - 01/2017
3Vascular Remodeling
01/2021 - 10/2013
3Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2021 - 12/2012
3Glucose Intolerance
01/2021 - 01/2013
3Pathologic Constriction (Stenosis)
01/2018 - 05/2005

Drug/Important Bio-Agent (IBA)

51Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2023 - 04/2002
23Proteins (Proteins, Gene)FDA Link
04/2024 - 01/2002
21LipidsIBA
04/2024 - 03/2003
17Vascular Endothelial Growth Factor DIBA
01/2021 - 09/2002
15Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2018 - 01/2002
14Vascular Endothelial Growth Factor CIBA
06/2019 - 07/2002
12Vascular Endothelial Growth Factor BIBA
04/2024 - 08/2005
12Lipoproteins (Lipoprotein)IBA
04/2024 - 08/2002
12CholesterolIBA
01/2021 - 08/2002
12Thymidine KinaseIBA
01/2020 - 11/2002
12Ganciclovir (Cytovene)FDA LinkGeneric
01/2020 - 04/2002
10RNA (Ribonucleic Acid)IBA
04/2024 - 04/2013
10Vascular Endothelial Growth FactorsIBA
01/2023 - 05/2006
10Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA
06/2015 - 07/2002
9Apolipoprotein B-100 (Apo B 100)IBA
01/2023 - 11/2007
9AntibodiesIBA
01/2022 - 03/2003
9Glucose (Dextrose)FDA LinkGeneric
01/2021 - 01/2003
9Insulin-Like Growth Factor II (Somatomedin A)IBA
03/2019 - 11/2007
9LDL Receptors (LDL Receptor)IBA
01/2019 - 08/2005
8Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
11/2022 - 04/2002
8Messenger RNA (mRNA)IBA
10/2021 - 02/2007
8Transcription Factors (Transcription Factor)IBA
01/2019 - 06/2005
7MicroRNAs (MicroRNA)IBA
01/2022 - 07/2008
7LigandsIBA
10/2021 - 03/2002
7oxidized low density lipoproteinIBA
03/2019 - 08/2002
7DNA (Deoxyribonucleic Acid)IBA
01/2019 - 11/2002
6ApolipoproteinsIBA
02/2016 - 01/2003
6CytokinesIBA
02/2016 - 01/2002
5Therapeutic UsesIBA
10/2021 - 01/2002
5Angiopoietin-2IBA
01/2020 - 12/2010
5Apolipoproteins E (ApoE)IBA
01/2019 - 03/2003
5EnzymesIBA
08/2013 - 11/2003
5AvidinIBA
12/2012 - 12/2003
4Oxygen (Dioxygen)IBA
11/2023 - 11/2003
4Peptides (Polypeptides)IBA
10/2021 - 05/2008
4Biomarkers (Surrogate Marker)IBA
01/2020 - 09/2014
4Monoclonal AntibodiesIBA
01/2020 - 12/2003
4ProdrugsIBA
01/2020 - 10/2009
4Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
06/2019 - 05/2008
4Small Interfering RNA (siRNA)IBA
01/2019 - 05/2012
4Triglycerides (Triacylglycerol)IBA
10/2018 - 09/2013
4NF-kappa B (NF-kB)IBA
07/2012 - 01/2003
3Protein Isoforms (Isoforms)IBA
04/2024 - 10/2010
3ChromatinIBA
03/2024 - 04/2015
3VaccinesIBA
11/2023 - 10/2021
3Paclitaxel (Taxol)FDA LinkGeneric
01/2022 - 08/2009
3Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
01/2020 - 04/2009
3Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
01/2020 - 02/2006
3TIE-2 Receptor (Receptor, TIE 2)IBA
01/2020 - 03/2003
3AntioxidantsIBA
01/2019 - 08/2002
3Insulin (Novolin)FDA Link
01/2019 - 01/2003
3Retinaldehyde (Retinal)IBA
08/2018 - 02/2012
3AngiopoietinsIBA
01/2017 - 12/2010

Therapy/Procedure

57Therapeutics
05/2024 - 04/2002
6Stents
10/2021 - 06/2003
6Radiotherapy
06/2015 - 11/2004
4Surgical Amputation (Amputations)
01/2023 - 04/2002
4Drug Therapy (Chemotherapy)
01/2022 - 03/2013
3Injections
01/2024 - 11/2002
3Transplantation
01/2023 - 12/2007
3Photochemotherapy (Photodynamic Therapy)
03/2018 - 02/2011